Summary Data

cfr infographic09jun22

TABLE 1. FAMILY RECRUITMENT

	Male	Female	Total

Population-based Families^a			13,188
Case probands^{c, f}	4,321	4,418	8,739
Affected relatives^{e, f}	339	380	719
Unaffected relatives^{e, g}	7,397	9,960	17,357
Spouse Controls^{g, h}	363	561	924
Unrelated control probands^{g, i}	2,071	2,204	4,275
Relatives of controls (Australia only)^j	310	467	777
Total population-based individuals	14,801	17,990	32,791

Clinic-based Families^b			1,860
Affected probands^{d, f}	707	648	1,355
Unaffected probands^{d, g}	130	300	430
Affected relatives^{e, f}	444	467	912
Unaffected relatives^{e, g}	3,079	3,933	7,012
Total clinic-based individuals	4,360	5,348	9,709

Total Individuals	19,161	23,338	42,500
Total Families			15,048

TABLE 2. FAMILY DATA

		Male	Female	Total
A. Population-Based Case Families^a
Case Probands^{c, f}	Baseline epidemiologic/risk factor survey data^k	4,321	4,418	8,739
	1st Follow-upepidemiologic/risk factor survey data^l	2,652	2,980	5,632
	2nd Follow-up epidemiologic/risk factor survey data^l	1,883	2,160	4,043
	3rd Follow-up epidemiologic/risk factor survey data^l	1,240	1,491	2,731
	4th Follow-up epidemiologic/risk factor survey data^l	548	701	1,249
	Food Frequency Questionnaire (FFQ) data^m	2,094	2,406	4,500
	Blood/buccal samples	3,478	3,628	7,106
	Polyp material	18	11	29
	Tumor material:	3,574	3,452	7,026
	CRC tumor material^{f, n}	3,532	3,389	6,921
	Other (extracolonic) tumor material^o	98	153	251
	Clinical diagnosis and treatment data^p	2,048	2,004	4,052
Relatives^e	Baseline epidemiologic/risk factor survey data^k	7,736	10,340	18,076
	1st Follow-up epidemiologic/risk factor survey data^l	6,055	8,344	14,399
	2nd Follow-up epidemiologic/risk factor survey data^l	4745	6,690	11,435
	3rd Follow-up epidemiologic/risk factor survey data^l	3280	4,671	7,951
	4th Follow-up epidemiologic/risk factor survey data^l	1520	2,225	3,745
	Food Frequency Questionnaire (FFQ) data^m	3274	4,619	7,893
	Blood/buccal samples	4115	5,817	9,932
	Polyp material	9	12	21
	Tumor material:	315	385	700
	CRC tumor material^{f, n}	248	261	509
	Other (extracolonic) tumor material^o	80	147	227
	Clinical diagnosis and treatment data^p	52	54	106
Spouse Controls^{h, g}	Baseline epidemiologic/risk factor survey data^k	363	561	924
	1st Follow-up epidemiologic/risk factor survey data^l	296	484	780
	2nd Follow-up epidemiologic/risk factor survey data^l	233	398	631
	3rd Follow-up epidemiologic/risk factor survey data^l	173	304	477
	4th Follow-up epidemiologic/risk factor survey data^l	94	158	252
	Food Frequency Questionnaire (FFQ) data^m	211	318	529
	Blood/buccal samples	259	409	668
	Polyp material	0	0	0
	Tumor material:	4	10	14
	CRC tumor material^{f, n}	1	4	5
	Other (extracolonic) tumor material^o	3	6	9
	Clinical diagnosis and treatment data^p	0	0	0
B. Population-Based Control Families
Probandsⁱ	Baseline epidemiologic/risk factor survey data^k	2,071	2,204	4,275
	1st Follow-up epidemiologic/risk factor survey data^l	668	591	1,259
	2nd Follow-up epidemiologic/risk factor survey data^l	335	279	614
	3rd Follow-up epidemiologic/risk factor survey data^l	0	0	0
	4th Follow-up epidemiologic/risk factor survey data^l	0	0	0
	Food Frequency Questionnaire (FFQ) data^m	1,151	1,024	2,175
	Blood/buccal samples	1,356	1,419	2,775
	Polyp material	0	0	0
	Tumor material:	0	0	0
	CRC tumor material^{f, n}	0	0	0
	Other (extracolonic) tumor material^o	0	0	0
	Clinical diagnosis and treatment data^p	0	0	0
Relatives^j	Baseline epidemiologic/risk factor survey data^k	310	467	777
	1st Follow-up epidemiologic/risk factor survey data^l	0	0	0
	2nd Follow-up epidemiologic/risk factor survey data^l	0	0	0
	3rd Follow-up epidemiologic/risk factor survey data^l	0	0	0
	4th Follow-up epidemiologic/risk factor survey data^l	0	0	0
	Food Frequency Questionnaire (FFQ) data^m	259	382	641
	Blood/buccal samples	5	5	10
	Polyp material	0	0	0
	Tumor material:	0	0	0
	CRC tumor material^{f, n}	0	0	0
	Other (extracolonic) tumor material^o	0	0	0
	Clinical diagnosis and treatment data^p	0	0	0

C. Clinic-Based Families^b
Affected Probands^{d, f}	Baseline epidemiologic/risk factor survey data^k	707	648	1,355
	1st Follow-up epidemiologic/risk factor survey data^l	511	502	1,013
	2nd Follow-up epidemiologic/risk factor survey data^l	390	409	799
	3rd Follow-up epidemiologic/risk factor survey data^l	240	254	494
	4th Follow-up epidemiologic/risk factor survey data^l	75	96	171
	Food Frequency Questionnaire (FFQ) data^m	236	252	488
	Blood/buccal samples	627	591	1,218
	Polyp material	21	24	45
	Tumor material:	590	538	1,128
	CRC tumor material^{f, n}	581	523	1,104
	Other (extracolonic) tumor material^o	77	98	175
	Clinical diagnosis and treatment data^p	358	295	653
Unaffected Probands^{d, g}	Baseline epidemiologic/risk factor survey data^k	130	300	430
	1st Follow-up epidemiologic/risk factor survey data^l	122	277	399
	2nd Follow-up epidemiologic/risk factor survey data^l	107	245	352
	3rd Follow-up epidemiologic/risk factor survey data^l	64	139	203
	4th Follow-up epidemiologic/risk factor survey data^l	20	48	68
	Food Frequency Questionnaire (FFQ) data^m	72	183	255
	Blood/buccal samples	111	264	375
	Polyp material	18	34	52
	Tumor material:	30	85	115
	CRC tumor material^{f, n}	2	8	10
	Other (extracolonic) tumor material^o	28	81	109
	Clinical diagnosis and treatment data^p	3	4	7
Relatives^e	Baseline epidemiologic/risk factor survey data^k	3,523	4,400	7,924
	1st Follow-up epidemiologic/risk factor survey data^l	3,017	3,820	6,838
	2nd Follow-up epidemiologic/risk factor survey data^l	2,483	3,206	5,690
	3rd Follow-up epidemiologic/risk factor survey data^l	1,506	2,043	3,549
	4th Follow-up epidemiologic/risk factor survey data^l	459	684	1,143
	Food Frequency Questionnaire (FFQ) data^m	1,922	2,564	4,486
	Blood/buccal samples	3,007	3,860	6,868
	Polyp material	124	133	257
	Tumor material:	485	605	1,090
	CRC tumor material^{f, n}	338	375	713
	Other (extracolonic) tumor material^o	173	277	450
	Clinical diagnosis and treatment data^p	15	6	21

a. Population-based families include colorectal cancer (CRC)-affected case probands ascertained through regional, state or provincial cancer registries and their CRC-affected and -unaffected family members (all CCFR sites); unrelated population-based control probands (Fred Hutch/Seattle, Sinai Health System/Ontario, Univ of Melbourne/Australia); spouse controls (Mayo Clinic, Univ of Hawaii, Univ of Melbourne/Australia), unaffected family member controls (Cedars-Sinai/USC consortium).

b. Clinic-based families include CRC-affected and -unaffected probands ascertained through genetic and family cancer clinics and their CRC-affected and unaffected family members(Cleveland Clinic, Fred Hutch/Seattle, Mayo Clinic, Sinai Health System/Ontario, Univ of Melbourne/Australia).

c. Population-based colorectal cancer (CRC)-affected case probands ascertained through regional, state or provincial cancer registry.

d. Clinic-based probands, defined as the first family member ascertained through a genetic or family cancer clinic. Clinic-based probands may be CRC-affected or -unaffected at baseline epidemiologic/risk factors survey.

e. Relative of proband includes blood and non-blood related and may be CRC-affected or -unaffected.

f. CRC-affected at baseline epidemiologic/risk factors survey. CRC is defined as a malignant tumor in ICD-0 sites codes C18.0 - C18.9, C19.9, C20.0, C21.8, and C26.0.

g. CRC-unaffected at baseline epidemiologic/risk factors survey.

h. Spouse of population-based case proband recruited to serve as a control (Mayo Clinic, Univ of Hawaii, Univ of Melbourne/Australia, and UCSF).

i. Unrelated population-based control probands unaffected with CRC at baseline and ascertained through Medicare, driver's license files, telephone subscription lists or electoral roles (Fred Hutch/Seattle, Sinai Health System/Ontario, Univ of Melbourne/Australia).

j. Family members of population-based controls (Australia). These may be CRC-affected or -unaffected.

k. Baseline epidemiologic/risk factor survey data (excluding proxy completion)

l. Follow-up epidemiologic/risk factor survey data. These are attempted every 4-5 years beginning in Phase II among Phase I enrollees (excluding population-based controls).

m. Food Frequency Questionnaire (FFQ). Hawaii FFQ version administered at baseline (Sinai Health System/Ontario, Univ of Hawaii, UCSF, Cedars-Sinai/USC consortium, Cleveland Clinic). Australia FFQ administered at baseline (Univ of Melbourne/Australia).

n. Individuals diagnosed with colorectal cancer and at least one colorectal tumor specimen obtained.

o. Individuals diagnosed with extracolonic cancer and at least one tumor specimen obtained.

p. Clinical diagnosis and treatment data were collected approximately 4 years after CRC diagnosis for Phase I enrolled CRC-affected probands (all sites except Cedars-Sinai/USC consortium and UCSF).

Summary Data - May 2022

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